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分子印迹聚合物-流动注射-化学发光法测定磺胺脒
          
Determination of Sulfaguanidine by Flow Injection Chemiluminescence Based on Molecularly Imprinted Polymer

摘    要
以磺胺脒为目标分子,二乙烯三胺为功能单体,环氧树脂为交联剂,合成对磺胺脒具有专一性识别的分子印迹聚合物(MIP),再将其制备成化学发光传感器,采用流动注射-化学发光法测定磺胺脒。样品溶液经传感器吸附120 s后,用水洗涤传感器30 s,传感器上吸附的磺胺脒与0.6 mol·L-1盐酸-1×10-3mol·L-1高锰酸钾-8%(体积分数)甲醛混合溶液发生化学发光反应,反应时间为160 s。磺胺脒的浓度在5×10-5~1.0×10-3mol·L-1内与化学发光强度呈线性关系,检出限(3S/N)为1×10-6mol·L-1。按标准加入法对复方磺胺脒片进行回收试验,回收率为94.3%~98.5%,测定值的相对标准偏差(n=6)小于4.0%。
标    签 磺胺脒   分子印迹   流动注射   化学发光   传感器   sulfaguanidine   moleculary imprinting   flow injection   chemiluminescence   sensor  
 
Abstract
A molecularly imprinted polymer for specific recognition of sulfaguanidine was synthesized by using sulfaguanidine as the template molecule, diethylenetriamine as the monomer, and epoxy resin as the cross-linking reagent. Then it was used to prepare a chemiluminescent sensor for detemiantion of sulfaguanidine by flow injection chemiluminescence. After the sample solution was adsorbed by the sensor for 120 s, the sensor was washed with water for 30 s. Then sulfadiazine adsorbed on the sensor reacted with a mixed solution of 0.6 mol·L-1 HCl-1×10-3mol·L-1 KMnO4-8% (volume fraction) formaldehyde for 160 s to generate chemiluminescent signal. Linear relationship was found between chemiluminescence intensity with concentration of sulfaguanidine in the range of 5×10-5-1.0×10-3mol·L-1, with detection limit (3S/N) of 1×10-6mol·L-1. Tests for recovery to compound sulfanilamide tablets were made by standard addition method, giving results in the range of 94.3%-98.5%, and RSDs (n=6) were less than 4.0%.

中图分类号 O657.3   DOI 10.11973/lhjy-hx201803005

 
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所属栏目 工作简报

基金项目 重庆市教委科技项目(KJ130650);中国科学院“百人计划”基金资助项目(Y410021011);国家自然基金项目(21267018)

收稿日期 2017/2/28

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备注谭利(1994-),男,重庆开县人,硕士研究生,研究方向为药物分析化学

引用该论文: TAN Li,XIANG Hui,YUAN Silan,ZHANGLUO Yilan,ZHENG Hong. Determination of Sulfaguanidine by Flow Injection Chemiluminescence Based on Molecularly Imprinted Polymer[J]. Physical Testing and Chemical Analysis part B:Chemical Analysis, 2018, 54(3): 269~274
谭利,向辉,袁丝兰,张罗一览,郑红. 分子印迹聚合物-流动注射-化学发光法测定磺胺脒[J]. 理化检验-化学分册, 2018, 54(3): 269~274


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