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电位滴定法测定盐酸左氧氟沙星注射液中左氧氟沙星的含量
          
Determination of Levofloxacin in Injections of Levofloxacin Hydrochloride by Potentiometric Titration

摘    要
对测定盐酸左氧氟沙星注射液中有效成分左氧氟沙星含量的电位滴定法提出了改进,即在盐酸左氧氟沙星注射液样品中加入1.0~2.0倍于左氧氟沙星的物质的量的盐酸标准溶液,以0.050 mol·L-1氢氧化钠标准溶液进行滴定,根据滴定曲线上第一个与第三个pH突跃点之间的体积差值计算左氧氟沙星的含量。按上述方法测定可消除样品中可能存在的游离盐酸或游离左氧氟沙星对测定带来的误差。4种不同批次注射液的测定结果与高效液相色谱法的测定结果相近,测定值的相对标准偏差(n=5)均小于0.30%。按标准加入法进行回收试验,回收率为97.6%~102%。
标    签 电位滴定法   盐酸左氧氟沙星注射液   左氧氟沙星   potentiometric titration   injection of levofloxacin hydrochloride   levofloxacin  
 
Abstract
A modification was made for the potentiometric titration of the effective ingredient——levofloxacin in injections of levofloxacin hydrochloride, by addition of an appropriate amount of standard hydrochloric acid to the injection sample with its amount of substance 1.0 to 2.0 times that of the levofloxacin, and using 0.050 0 mol·L-1 NaOH standard solution as titrant. The difference of volumes of titrants between the 3rd and 1st sudden peaks of pH in the titration curve was taken to calculate the amount of levofloxacin in the injection sample. The errors due to free HCl or free levofloxacin, which may be present in the sample, were thus eliminated. Samples of the injections taken from 4 separated batches were analyzed by this modified procedure, giving results in consistency with those found by HPLC. Values of RSDs (n=5) of the modified method were found all less than 0.30%. Test for recovery was made by standard addition method, giving values of recovery in the range of 97.6%-102%.

中图分类号 O657.12   DOI 10.11973/lhjy-hx201807005

 
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所属栏目 工作简报

基金项目 中央高校基本科研业务费专项资金(2017IB007)

收稿日期 2017/7/27

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备注黄偲睿,硕士研究生,主要从事分析测试技术的研究工作

引用该论文: HUANG Cairui,WANG Huiling,SHEN Congcong,CAI Hongwei. Determination of Levofloxacin in Injections of Levofloxacin Hydrochloride by Potentiometric Titration[J]. Physical Testing and Chemical Analysis part B:Chemical Analysis, 2018, 54(7): 766~769
黄偲睿,王慧玲,申聪聪,蔡宏伟. 电位滴定法测定盐酸左氧氟沙星注射液中左氧氟沙星的含量[J]. 理化检验-化学分册, 2018, 54(7): 766~769


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